THE SYSTEMIC RESPONSE TO TOPICAL ALDARA TREATMENT IS MEDIATED THROUGH DIRECT TLR7 STIMULATION AS IMIQUIMOD ENTERS THE CIRCULATION

The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation

Abstract Topical application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely used mouse model for investigating the pathogenesis of psoriasis.We have previously used this model to study the effects of peripheral inflammation on the brain, and reported a brain-specific response characterised by increased transcr

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Evaluation of Radar Backscattering Models IEM, OH, and Dubois using L and C-Bands SAR Data over different vegetation canopy covers and soil depths

Several algorithms have been proposed in the literature to invert radar measurements to estimate surface soil moisture.The objective of this paper is to Plush Toys compare the performance of the most common surface back scattering models including the theoretical integral equation model (IEM) of Fung et al.(1992), and the semi-empirical models of O

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